Spiegler-Fendt type lymphocytoma cutis: a case report of two patients successfully treated with interferon alpha-2b.

Sir, Lymphocytoma cutis of Spiegler-Fendt type is a rare chronic B lymphocyte proliferation a¡ecting the head and the neck in particular. It is characterized by solitary or grouped nodules or plaques which are purple or red and may reach a diameter of 3 ^ 5 cm. Although lymphocytoma cutis is a benign disorder, it often runs a protracted, even life-long course. Progression to malignant B cell lymphoma in a small percentage of patients is suggested by long-term follow-up of these patients. A therapy of proven value for lymphocytoma cutis is, however, lacking. We report here 2 cases of lymphocytoma cutis which were successfully treated with interferon alpha-2b. Both patients had previously received various unsuccessful therapies, but responded well to interferon.